Dutch side Ajax claimed the scalp of Manchester City with a 3-1 victory in their Champions League Group D match, a result which leave City bottom of the group and in serious danger of being eliminated from the competition.
Arsenal were also beaten, losing 2-0 at home to Schalke. The Gunners remain second in Group A, a point behind the Bundesliga side.
Real Madrid were on the receiving end of a 2-1 loss to Borussia Dortmund in Group D but both clubs have a healthy lead over Ajax and Man City.
Group C leaders Malaga looked good value for the 1-0 home win against a struggling AC Milan leaving the Italians five points adrift of the Spanish club.
Tonight Tottemham Hotspur travel to Maribor for their Europa League Group J game with a number of first team players missing including Gareth Bale and Emmanuel Adebayor.
Newcastle are home to Belgium club Brugge and Liverpool will want the Anfield supporters to give them a lift for their tie against Russian club Makhachkala.
Italian clubs could be in for a testing night. Inter could have a bruising encounter withPartisan Belgrade. Lazio are away to Greek side Panathiaiikos, Udinese travel to Swiss club BSC Young Boys and Napoli visit Dnipropetrovsk of Ukraine